| 188* | G Kirsten | v United Arab Emirates at Rawalpindi, World Cup, 1995/96 [1049] |
| 175 | HH Gibbs | v Australia at Johannesburg, 5th ODI, 2005/06 [2349] |
| 169* | DJ Callaghan | v New Zealand at Verwoerdburg, Mandela Trophy, 1994/95 [960] |
| 161 | AC Hudson | v Netherlands at Rawalpindi, World Cup, 1995/96 [1073] |
| 153 | HH Gibbs | v Bangladesh at Potchefstroom, 1st ODI, 2002/03 [1890] |
| 147* | MV Boucher | v Zimbabwe at Potchefstroom, 3rd ODI, 2006 [2420] |
| 146 | AB de Villiers | v West Indies at St George's, ICC World Cup, 2006/07 [2567] |
| 143 | HH Gibbs | v New Zealand at Johannesburg, World Cup, 2002/03 [1955] |
| 139 | JH Kallis | v West Indies at Johannesburg, 5th ODI, 2003/04 [2096] |
| 134* | GC Smith | v India at Kolkata, 4th ODI, 2005/06 [2299] |
| 133* | G Kirsten | v India at Johannesburg, Standard Bank Series, 2001/02 [1752] |
| 131* | ND McKenzie | v Kenya at Cape Town, Standard Bank Series, 2001/02 [1763] |
| 129 | N Boje | v New Zealand at Centurion, 3rd ODI, 2000/01 [1647] |
| 128* | JH Kallis | v Netherlands at Basseterre, ICC World Cup, 2006/07 [2537] |
| 127 | BM McMillan | v Zimbabwe at Harare, 1st ODI, 1995/96 [1013] |
| 125* | JH Kallis | v Zimbabwe at Canterbury, NatWest Series, 2003 [2030] |
| 125* | HH Dippenaar | v Sri Lanka at Adelaide, VB Series, 2005/06 [2318] |
| 125 | HH Gibbs | v West Indies at Port Elizabeth, 4th ODI, 1998/99 [1397] |
| 125 | HH Gibbs | v Zimbabwe at Bulawayo, 1st ODI, 2001/02 [1748] |
| 124 | DJ Cullinan | v Pakistan at Nairobi (Gymk), KCA Centenary Tournament, 1996/97 [1121] |
| 124 | G Kirsten | v Kenya at Cape Town, Standard Bank Series, 2001/02 [1763] |
| 123 | HH Dippenaar | v West Indies at Barbados, 3rd ODI, 2004/05 [2243] |
| 121 | JN Rhodes | v Pakistan at Nairobi (Gymk), KCA Centenary Tournament, 1996/97 [1121] |
| 120* | ND McKenzie | v Sri Lanka at East London, 2nd ODI, 2000/01 [1662] |
| 119* | GC Smith | v Australia at Centurion, 1st ODI, 2005/06 [2341] |
| 119* | JH Kallis | v India at Durban, 2nd ODI, 2006/07 [2447] |
| 118* | G Kirsten | v Pakistan at Nairobi (Gymk), KCA Centenary Tournament, 1996/97 [1126] |
| 118 | HH Gibbs | v England at Durban, 6th ODI, 2004/05 [2225] |
| 117 | GC Smith | v Zimbabwe at Durban, 2nd ODI, 2004/05 [2231] |
| 116* | HH Gibbs | v India at Colombo (RPS), ICC Champions Trophy, 2002/03 [1886] |
| 116 | G Kirsten | v England at Centurion, 4th ODI, 1995/96 [1038] |
| 116 | HH Gibbs | v Kenya at Colombo (RPS), ICC Champions Trophy, 2002/03 [1882] |
| 115* | G Kirsten | v India at Sharjah, Sharjah Cup, 1995/96 [1101] |
| 115* | GC Smith | v England at East London, 5th ODI, 2004/05 [2224] |
| 115 | G Kirsten | v India at Kochi, 1st ODI, 1999/00 [1572] |
| 114 | HH Gibbs | v Pakistan at Tangier, Morocco Cup, 2002 [1860] |
| 113* | JH Kallis | v Sri Lanka at Dhaka, Wills International Cup, 1998/99 [1362] |
| 112* | G Kirsten | v Australia at Melbourne, World Series, 1993/94 [876] |
| 112 | WJ Cronje | v Australia at Johannesburg, 1st ODI, 1993/94 [882] |
| 111 | JH Kallis | v New Zealand at Perth, Carlton & United Series, 1997/98 [1278] |
| 111 | HH Gibbs | v India at Kochi, 1st ODI, 1999/00 [1572] |
| 110* | DJ Cullinan | v Pakistan at Sharjah, Sharjah Cup, 1995/96 [1095] |
| 110* | HH Dippenaar | v Pakistan at Lahore, 1st ODI, 2003/04 [2046] |
| 109* | JH Kallis | v Pakistan at Durban, Standard Bank Series, 1997/98 [1303] |
| 109* | JH Kallis | v West Indies at Cape Town, 1st ODI, 2003/04 [2088] |
| 108* | HH Gibbs | v Sri Lanka at Kimberley, 4th ODI, 2002/03 [1911] |
| 108 | AC Hudson | v India at Bloemfontein, 5th ODI, 1992/93 [781] |
