| 120 | KN Young | v Pakistan Women at Dublin, 3rd ODI, 2000 [327] |
| 114* | MP Moore | v Denmark Women at Dublin, Women's European Championship, 1995 [198] |
| 101 | ME Grealey | v Pakistan Women at Rush, 2nd ODI, 2000 [326] |
| 99 | MP Moore | v Denmark Women at Kirby Muxloe, Women's European Championship, 1990 [132] |
| 95* | CMA Shillington | v Netherlands Women at Miskin, Women's European Championship, 2005 [541] |
| 84* | S Owens | v Netherlands Women at Nottingham, Women's European Championship, 1990 [134] |
| 78* | CM Beggs | v Netherlands Women at Miskin, Women's European Championship, 2005 [541] |
| 77 | CNIM Joyce | v Netherlands Women at Miskin, Women's European Championship, 2005 [541] |
| 77 | CM Beggs | v Netherlands Women at Dublin, 3rd ODI, 2006 [573] |
| 74 | A Linehan | v Denmark Women at Dublin, Women's European Championship, 1995 [198] |
| 67* | IMHC Joyce | v New Zealand Women at Dublin, 2nd ODI, 2004 [489] |
| 66* | CM Beggs | v Netherlands Women at Christchurch, CricInfo Women's World Cup, 2000/01 [356] |
| 66 | S Owens | v Netherlands Women at Perth, Shell Bicentennial Women's World Cup, 1988/89 [103] |
| 63* | ME Grealey | v Denmark Women at Oxford, Women's World Cup, 1993 [164] |
| 63* | CM Beggs | v India Women at Dublin, 2nd ODI, 2006 [568] |
| 62 | ME Grealey | v Pakistan Women at Gurgaon, Hero Honda Women's World Cup, 1997/98 [263] |
| 61* | ME Grealey | v Pakistan Women at Rotterdam, IWCC Trophy, 2003 [443] |
| 61 | A Murrey | v Denmark Women at Kirby Muxloe, Women's European Championship, 1990 [132] |
| 61 | S Owens | v Denmark Women at Oxford, Women's World Cup, 1993 [164] |
| 60* | A Murrey | v Denmark Women at Nykobing Mors, Women's European Championship, 1989 [122] |
| 60 | S Reamsbottom | v West Indies Women at Dorking, Women's World Cup, 1993 [186] |
| 60 | CM Beggs | v Pakistan Women at Dublin, 3rd ODI, 2000 [327] |
| 59 | MP Moore | v Netherlands Women at Dublin, Women's European Championship, 1995 [201] |
| 58 | A Murrey | v England Women at Sydney, Shell Bicentennial Women's World Cup, 1988/89 [107] |
| 57 | ME Grealey | v South Africa Women at Pune, Hero Honda Women's World Cup, 1997/98 [253] |
| 57 | ME Grealey | v Australia Women at Dublin, 2nd ODI, 2001 [374] |
| 56 | A Linehan | v Netherlands Women at Dublin, Women's European Championship, 1995 [201] |
| 56 | CM Beggs | v New Zealand Women at Dublin, 2nd ODI, 2002 [407] |
| 54* | MP Moore | v New Zealand Women at Melbourne, Shell Bicentennial Women's World Cup, 1988/89 [120] |
| 54 | A Linehan | v Netherlands Women at Christchurch, CricInfo Women's World Cup, 2000/01 [356] |
| 53* | CM O'Leary | v Pakistan Women at Rush, 1st ODI, 2000 [325] |
| 51* | CM Beggs | v Pakistan Women at Dublin, 4th ODI, 2000 [328] |
| 50* | EAJ Richardson | v Netherlands Women at Dublin, 2nd ODI, 2006 [572] |
